Epigenomic technologies are giving drug researchers a way to examine how gene activity is regulated, adding information that DNA sequencing and RNA expression measurements alone may not provide. A GEN eBook examines how these insights can support multiple stages of drug discovery and development.
The eBook covers the use of epigenomic profiling to identify and validate potential therapeutic targets, investigate how drugs work, study treatment resistance and optimize therapies. It also discusses emerging approaches such as targeted protein degraders, including PROTACs and molecular glues.
Among the technologies highlighted is CUT&RUN, a chromatin-mapping method presented as a tool for investigating the regulatory mechanisms behind gene expression. The publication uses expert perspectives and case studies to show how epigenomic approaches can help researchers characterize biological processes and therapeutic responses.
The resource is aimed at people working in target discovery, translational research and therapeutic development, and outlines how epigenomic tools can inform research and development decisions.